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In line with previous reports 15,16,17 , patients with severe COVID-19 had increased concentrations of inflammatory cytokines in comparison to patients with moderate symptoms or uninfected control individuals (Fig

Xie P, Zhang M, He S, Lu K, Chen Y, Xing G, et al

which first documented that MOTS-c increases cellular NAD+ levels and activates AMPK through SIRT1, MOTS-c also increases cellular NAD+ levels as part of its activation of AMPK through SIRT1

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[DOI] [PubMed] [Google Scholar] 28.Zhang L., Zhou F., Ten Dijke P

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